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Publications (2013-) (Total citations: 7128; h-index: 48)

1. Cruz, S. A., P. L. Chao and P. P. Hwang* (2013) Cortisol promotes differentiation of epidermal ionocytes through Foxi3 transcription factors in zebrafish (Danio rerio). Comp. Biochem. Physiol. A. 164: 249-257.


2. Kang, C. K., W. K. Yang, S. T. Lin, C. C. Liu, H. M. Lin, H. H. Chen, C. W. Cheng, T. H. Lee and P. P. Hwang* (2013) The acute and regulatory phases of time-course changes in gill mitochondrion-rich cells of seawater-acclimated medaka (Oryzias dancena) when exposed to hypoosmotic environments. Comp. Biochem. Physiol. A. 164: 181-191.


3. Liao, W. H., C. H. Cheng, K. S. Hung, W. T. Chiu, G. D. Chen, P. P. Hwang*, S. P. Hwang, Y. S. Kuan and C. J. Hwang (2013) Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling. Cell Mol. Life Sci. 70: 2367-2381.


4. Yang, W. K., C. K. Kang, C. H. Chang, A. D. Hsu, T. H. Lee and P. P. Hwang* (2013) Expression profiles of branchial FXYD proteins in the brackish medaka Oryzias dancena: a potential saltwater fish model for studies of osmoregulation. PLoS One. 8: e55470.


5. Tseng, Y. C., Z. J. Kao, S. T. Liu, R. D. Chen and P. P. Hwang* (2013) Spatial expression and functional flexibility of monocarboxylate transporter isoforms in the zebrafish brain. Comp. Biochem. Physiol. A. 165:106-118.


6. Tseng. Y. C., M. Y. Hu, M. Stumpp, L. Y. Lin, F. Melzner and P. P. Hwang* (2013) CO2- driven seawater acidification differentially affects development and molecular plasticity along life history of fish (Oryzias latipes). Comp. Biochem. Physiol. A. 165:191-130.


7. Hwang, P. P.* and M. Y. Chou (2013) Zebrafish as an animal model to study ion homeostasis. Pflugers Arch - Eur. J. Physiol. 465: 1233-1247. (Invited Review Article)


8. Cruz, S. A., C. H. Lin, P. L. Chao and P. P. Hwang* (2013) Glucocorticoid receptor, but not mineralocorticoid receptor, mediates cortisol regulation of epidermal ionocyte development and ion transport in zebrafish (Danio rerio). PLoS One. 8: e77997.


9. Chang, W. J., F. F. Wang, H. J. Hu, J. H. Wang T. H. Lee and P. P. Hwang* (2013) Compensatory regulation of Na+ absorption by Na+/H+ exchanger and Na+-Cl- cotransporter in zebrafish (Danio rerio). Front. Zool. 10: 46.


10. Hu, M., Y., J. R. Lee, L. Y. Lin, T. H, Shih, M. Stumpp, M. F. Lee, P. P. Hwang* and Y. C. Tseng (2013) Development in a naturally acidified environment: Na+/H+ -exchanger 3-based proton secretion leads to CO2 tolerance in cephalopod embryos Front. Zool. 10: 51.


11. Lien, H. W., C. H. Yang, C. H. Cheng, C. C. Hung, W. H. Liao, P. P. Hwang, Y. S. Han, J. C. Huang* (2013) A novel zinc finger protein 219-like (ZNF219L) is involved in the regulation of collagen type 2 Alpha 1a (col2a1a) gene expression in zebrafish notochord. Int. J. Biol. Sci. 9: 872-886.


12. Lin, C. H., C. H. Su, and P. P. Hwang* (2013) Calcium-sensing receptor mediates Ca2+ homeostasis by modulating expression of PTH and stanniocalcin. Endocrinol.155: 56-67.


13. Trayer, V., P. P. Hwang, P. Prunet and V. Thermes* (2013) Assessment of the role of cortisol and corticosteroid receptors in epidermal ionocyte development in the medaka (Oryzias latipes) embryos. Gen. Comp. Endocrinol. 194: 152-161.


14. Han, H. W., C. M. Chou, C. Y. Chu, C. H. Cheng, C. H. Yang, C. C. Hung, P. P. Hwang, S. J. Lee, Y. F. Liao, and C. J. Huang (2014) The Nogo-C2/Nogo receptor complex regulates the morphogenesis of zebrafish lateral line primordium through modulating the expression of dkk1b, a Wnt signal inhibitor. PoS One. 9:e86345.


15. Guh, Y. J., Y. C. Tseng, C. Y. Yang and P. P. Hwang* (2014) Endothelin-1 regulates H+-ATPase-dependent transepithelial H+ secretion in zebrafish. Endorcinol. 155: 1728-1737.


16. Cheng, C.H., C. M. Chou, C. Y. Chu, G. D. Chen, H. W. Lien, P. P. Hwang, M. S. Chang and C. J. Huang (2014) Differential regulation of Tetraodon nigroviridis Mx gene promoter activity by constitutively-active forms of STAT1, STAT2, and IRF9. Fish Shellfish Immunol. 38: 230-243.


17. Hsu, H. H., L. Y. Lin, Y. C. Tseng, J. L. Horng and P. P. Hwang* (2014) A new model for fish ion regulation: Identification of ionocytes in freshwater- and seawater-acclimated medaka (Oryzias latipes). Cell Tissue Res. 357: 225-243.


18. Tseng, Y. C., S. T. Liu, M. Y. Hu, R. D. Cheng, J. R. Lee and P. P. Hwang* (2014) Brain functioning under acute hypothermic stress supported by dynamic monocarboxylate utilization and transport in ectothermic fish. Front. Zool. 11: 53.


19. Hu, M. Y., Y. J. Guh, M. Stumpp, J, R, Lee, R. D. Chen, P. H. Sung, Y. C. Chen, P. P. Hwang and Y. C. Tseng* (2014) Branchial NH4+-dependent acid–base transport mechanisms and energy metabolism of squid (Sepioteuthis lessoniana) affected by seawater acidification. Front. Zool. 11:55.


20. Chou, M. Y., P. L. Chao, J. C. Hung, S. A. Cruz and P. P. Hwang* (2015) Stanniocalcin-1 controls ion regulation functions of ion-transporting epithelium other than calcium balance. Int. J. Biol. Sci. 11: 122-132.


21. Shao, Y. T., Y. C. Tseng, C. H. Chang, H. Y. Yan, P. P. Hwang and B. Borg. (2015) GnRH mRNA levels in male three-spined sticklebacks, Gasterosteus aculeatus, under different reproductive conditions. Comp. Biochem. Physiol. A 180: 6-17.


22. Lin, S. J., D. Y. Lee, H. C. Wang, S. T. Kang, P. P. Hwang, G. H. Kou, M. F. Huang, G. D. Chang and C. F. Lo (2015) White Spot Syndrome Virus Protein Kinase 1 (PK1) Defeats the Host Cell's Iron Withholding Defense Mechanism by Interacting with Host Ferritin. J. Virol. 89: 1083-1093.


23. Furukawa, F., Y. C. Tseng, S. T. Liu, Y. L. Chou, C. C. Lin, P. H. Sung, K. Uchida, L. Y. Lin and P. P. Hwang* (2015) Induction of phosphoenolpyruvate carboxykinase (PEPCK) during acute acidosis and its role in acid secretion by V-ATPase-expressing ionocytes. Int. J. Biol. Sci. 11: 712-725.


24. Guh, Y. J., C. H. Lin and P. P. Hwang* (2015) Osmoregulation in zebrafish: ion transport mechanisms and functional regulation. EXCLI J. 14: 627-659. (Invited review article)


25. Stumpp, M., M. Y. Hu, Y. C. Tseng, Y. J. Guh, Y. C. Chen, J. K. Yu, Y. H. Su and P. P. Hwang* (2015) Evolution of extreme stomach pH in bilateria inferred from gastric alkalization mechanisms in basal deuterostomes. Sci. Rep. 5: 10421.


26. Hu, M. Y., P. P. Hwang* and Y. C. Tseng* (2015) Recent advances in understanding trans-epithelial acid-base regulation and excretion mechanisms in cephalopods. Tissue Barriers 3: e10641. (Invited review article)


27. Wang, Y. F., J. J. Yan, Y. C. Che, R. D. Chen and P. P. Hwang*. (2015) Molecular physiology of an extra-renal Cl- uptake mechanism for body fluid Cl- homeostasis. Int. J. Biol. Sci. 11: 1190-1203.


28. Lin, C. H., T, H Shih, S. T. Liu, H. H. Hsu and P. P. Hwang* (2015) Cortisol regulates acid secretion of H+-ATPase-rich ionocytes in zebrafish (Danio rerio) larvae. Front. Physiol. 6: 328.


29. Lin, C. H., H. J. Hu and P. P. Hwang* (2016) Cortisol regulates sodium homeostasis by stimulating the transcription of sodium-chloride transporter (NCC) in zebrafish (Danio rerio). Mol. Cell. Endocrinol. 422: 93-106.


30. Wu, B. K., R. Y. Yuan, H. W. Lien, C. C. Hung, P. P. Hwang, R. P. Chen, Y. F. Liao and C. J. Hwang* (2016) Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo. J. Biomed. Sci. 23: 25.


31. Guh, Y. J., C. Y. Yang, S. T, Liu, C. J. Huang and P. P. Hwang* (2016) Estrogen-related receptor α is required for transepithelial H+ secretion in zebrafish. Proc. Biol. Sci. 283: 20152582.


32. Lin, C. H., W. C. Kuan, B. K. Liao, A. N. Deng, D. Y. Tseng and P. P. Hwang* (2016) Environmental and cortisol-mediated control of Ca2+ uptake in tilapia (Oreochromis mossambicus). J. Comp. Physiol. 186: 323-332.


33. Wang, Y. F., A. G. Lafont, Y. C. Lee and P. P. Hwang* (2016) A novel function of calcitonin gene-related peptide in body fluid Cl- homeostasis. Proc. Biol. Sci. 283: 20160684.


34. Lien, H. W., R. Y. Yuan, C. M. Chou, Y. C. Chen, C. C. Hung, C. H. Hu, S. P. Hwang, P. P. Hwang, C. N. Shen, C. L. Chen, C. H. Cheng and C. J. Huang (2016) Zebrafish cyclin Dx is required for development of motor neuron progenitors, and its expression is regulated by hypoxia-inducible factor 2α. Sci. Rep. 6:28297.


35. Liu, S. T., J. L. Horng, P. Y. Chen, P. P. Hwang* and L. Y. Lin* (2016) Salt secretion is linked to acid-base regulation of ionocyte in seawater acclimated medaka: new insights into the salt secreting mechanism. Sci. Rep. 6:31433.


36. Guh, Y. J, and P. P. Hwang* (2016) Insights into Mmolecular and cellular mechanisms of hormonal actions on fish ion regulation: derived from the zebrafish as a model. Gen. Comp. Endocrinol. (accepted) (Invited Review Article)



Book chapters

1. Hwang P. P.* and L. Y. Lin (2014) Gill ion transport, acid-base regulation and nitrogen excretion. In: Evans D, Claiborne JB and Currie S (eds.) The Physiology of Fishes, 4th Edition. pp 205-233. Boca Raton: CRC Press.


2. Takei, Y. and P. P. Hwang* (2016) Homeostatic Responses to Osmotic Stress. In: Schreck C, Tort L (eds.) Fish Physiology-Biology of Stress in Fish. vol 35., San Diego: Elsevier Academia Press. (in press)